Oklahoma City took advantage of the short-handed Cavaliers with a 103-94 victory.
LeBron James sat out with left knee soreness, and without him, Cleveland's winning streak ended at eight games.
Oklahoma City's now-healthy dynamic duo took control as Russell Westbrook scored 26 points on 12-for-24 shooting with eight assists and seven rebounds, and Kevin Durant scored 19 points.
Kyrie Irving scored 20 points for Cleveland, but he made just 7 of 21 shots while struggling to finish against the ultra-athletic Westbrook.
Cavaliers at Thunder box score