Tony Parker scored 30 points, Manu Ginobili added 24 points and Kawhi Leonard had 17 points along with two key steals late to help the Spurs win their sixth straight.
Two nights after an emotional 111-87 victory over the Miami Heat in an NBA Finals rematch, the Spurs were listless against the Southeast Division's last-place team.
Tim Duncan added 11 points and 10 rebounds as San Antonio (46-16) tied Indiana and Oklahoma City for the league's best record.
Tobias Harris scored 23 points, Nikola Vucevic added 19 points and 13 rebounds for Orlando (19-45).