Harvard became the first team to reach the NCAA tournament, and the Crimson did it on rival Yale's court.
Senior guard Brandyn Curry had 14 points in in the 70-58 win over the Bulldogs on Friday night that secured the outright Ivy League championship.
Siyani Chambers scored 17 points and Steve Moundou-Missi added 16 for Harvard (25-4, 12-1), which won its seventh straight since losing its only conference game last month, to Yale in Cambridge.
Justin Sears had 28 points and 13 rebounds for the Bulldogs (15-12, 9-4). He was 11 of 16 from the floor. The rest of the team was 7 of 34.