Blake Griffin had 20 points and 11 rebounds during three thunderous quarters by the Clippers, who routed the Lakers 142-94 Thursday night to extend their winning streak to a season-best six games.
It was the most lopsided victory ever for the Clippers' franchise and the most one-sided loss in Lakers history.
Darren Collison had a team-high 24 points while starting at shooting guard for the injured Jamal Crawford. Chris Paul added 13 points and 11 assists for the Clippers, who have won the teams' past two meetings by a combined 84 points.
Pau Gasol had 21 points for the Lakers, the home team for the third of four meetings this season between the Staples Center co-tenants.