Dorian Finney-Smith scored 16 points, and Florida used a season-high 13 3-pointers to overwhelm the Tigers 79-61 and extend its school-record winning streak to 21 games.
Casey Prather and Michael Frazier II added 14 points apiece for the Gators, who also won their 31st straight at home.
Florida (27-2, 16-0 SEC) scored the first eight points of the game, opened up a double-digit lead with consecutive 3-pointers from DeVon Walker and Finney-Smith and put the game away early in the second half with a flurry of points in the paint.
Johnny O'Bryant III led the Tigers (17-11, 8-8) with 18 points. Jordan Mickey added 14 points and 10 rebounds for LSU, which lost its seventh straight on the road.