Patty Mills came off the bench to score 29 points, Marco Belinelli hit a go-ahead 3-pointer with 1:34 remaining and San Antonio rallied in the second half to pull out a 111-109 victory over the Trail Blazers.
San Antonio has won two of three games this season when Tim Duncan and Tony Parker were both absent from the lineup.
Mills helped fill the void with a 24-point second half. The fourth-year guard from Australia came off the bench to hit 13 of 26 shots against the Blazers. Belinelli had 20 points and Manu Ginobili 16 for San Antonio.
Damian Lillard scored 31 points, including 15 during the fourth quarter, for Portland.