Doug McDermott hit a falling-away, 25-footer with 2.5 seconds left to finish his season-high 39-point night, and No. 20 Creighton won 63-60 after squandering all of an 18-point lead Tuesday.
It was the second time this season McDermott won a game in the last seconds. He did it against Saint Joseph's in November.
The two-time returning All-America carried his team to its 13th win in 14 games, keeping the Bluejays (18-3, 8-1) in first place in the Big East. St. John's (12-9, 2-6), playing in Omaha for the first time since 1966, had its three-game winning streak end.