Montrezl Harrell led No. 3 Louisville with 20 points and nine rebounds in the Cardinals' 87-48 win over Hartford in the Hall of Fame Tipoff on Tuesday night.
He was 9 of 12 from the field with six dunks, one off the school record.
Russ Smith added 14 points as the Cardinals (4-0) extended their winning streak to 20 games dating to last season's run to the national title. Chris Jones and reserve Chane Behanan added 11 points apiece.
Louisville shot 50 percent from the field, outrebounded Hartford 35-29.
Mark Nwakamma scored 16 points for the Hawks (2-3), and reserve Yasin Kolo finished with 12.