The defending national champions shrugged off poor shooting, 19 turnovers and a subpar performance by star Russ Smith and still won handily Saturday to get back to the Sweet 16 of the NCAA tournament for the third straight year.
Luke Hancock scored 21 points and the battled-tested Cardinals (31-5) won with defense.
Saint Louis (27-7) missed all 15 of their 3-point shots and turned the ball over 18 times in losing in the third round for the third consecutive year.