Danny Green had 15 points and the Spurs won their ninth straight, defeating the Lakers 119-85 on Friday night for their largest victory over Los Angeles.
San Antonio never trailed after the opening four minutes, allowing coach Gregg Popovich to limit his starters and Manu Ginobili to an average of 17 minutes.
Pau Gasol had 18 points and 11 rebounds in 26 minutes and Jodie Meeks had 15 points for Los Angeles (22-44), which has lost five of six.
The Lakers suffered their most lopsided defeat to the Spurs since a 135-103 loss on Feb. 22, 1977. And it came eight days after their worst loss of this season, 142-94 to the Clippers.