Doug McDermott scored 32 points - 11 during a 14-2 run after DePaul pulled within a point in the second half - and the No. 12 Bluejays beat the Blue Demons 78-66 on Friday night.
The Bluejays (19-3, 9-1 Big East) have won 14 of their last 15 games. DePaul (10-14, 2-9) has lost six in a row.
Brandon Young had 16 points and Forrest Robinson added 11 for the Blue Demons.