Jabari Parker scored 21 points, Andre Dawkins tied a season-high with 20 and Duke pulled away from the Panthers 80-65.
The fifth-year senior made 6 of 7 3-point attempts, including three straight during a decisive 15-3 run midway through the second half that put the Blue Devils in front to stay.
Amile Jefferson chipped in a season-high 14 points for Duke (17-4, 6-2 ACC), which brought the Panthers' hot start in their first Atlantic Coast Conference season to an abrupt halt. The Blue Devils made 13 of 25 3-point attempts to hand Pitt (18-3, 6-2) its first loss at home.