Andrew Wiggins scored 22 points, Wayne Selden added 20 and the Jayhawks routed the 25th-ranked Wildcats 86-60 on Saturday for their sixth straight win in the series.
Joel Embiid contributed 11 points and nine rebounds, and Perry Ellis scored 12 as Kansas (11-4, 2-0 Big 12) shot 56 percent and committed just seven turnovers.
The Wildcats (12-4, 2-1), who had won their last 10 games, lost their seventh straight at Allen Fieldhouse and for the 48th time in the last 51 meetings. Nino Williams had 12 points and Thomas Gipson scored 10 to lead Kansas State, but top scorer Marcus Foster was held to just seven points on 3-of-12 shooting.