Montrezl Harrell had 17 points and eight rebounds, and Louisville manhandled the Bears 90-60 on Tuesday night.
The Cardinals (10-1) took control early and never let up against the Bears (8-2). They combined dominant rebounding and offensive accuracy during a 16-0 first-half run for a 19-4 lead in the first meeting between the schools since 2006.
Senior guard Russ Smith added 11 points and eight assists, while freshman Terry Rozier had 11 points and eight rebounds. Forwards Stephan Van Treese and Mangok Mathiang combined for 17 rebounds for Louisville, which shot 34 of 66 from the field (52 percent).