Blake Griffin scored 27 points, hitting 11 of 15 free throws, in the 115-92 win Monday night, 48 hours after returning to Los Angeles.
Chris Paul added 23 points, eight rebounds and seven assists, and Jamal Crawford had 17 points in his second straight start for the Clippers, who repelled several threats in the third quarter to maintain their lead.
Tim Duncan had 17 points and 11 rebounds for the Spurs, whose four-game winning streak ended. Tony Parker limped off the court with a right shin contusion with 5:09 left in the third.